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The application of antioxidant therapies aimed at lowering AGE could be a helpful tool because high AGE concentrations harm vascular smooth muscle and adversely affect NO function, which in turn impairs endothelial relaxation and prevents NO action against plaque formation from the oxidized form of LDL (Saleh, 2015)

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[DOI] [PubMed] [Google Scholar] [25].Caza TN, Fernandez D, Talaber G, et al